Alpha lipoic acid (ALA) and R lipoic acid (RLA) are organosulfur compounds with powerful antioxidant properties. The debate surrounding “alpha lipoic acid vs R lipoic acid” often revolves around the potency and effectiveness of each form. Understanding the differences between these two antioxidants can help you make informed decisions about which to choose to promote overall health and well-being.
You can combat oxidative stress and inflammation by taking RLA and ALA supplements. These free radicals, which are reactive oxygen species, can damage your cells. Vitamins C and E and antioxidants like ALA and RLA work together to scavenge these harmful molecules.
Key Takeaways
- Alpha lipoic acid and R lipoic acid are potent antioxidants with unique benefits.
- ALA and R-ALA help neutralize free radicals and reduce oxidative stress in the body
- Chemical structure and bioavailability play key roles in determining their effectiveness.
Definition of Alpha Lipoic Acid (ALA) and R Lipoic Acid (RLA)
ALA is an organosulfur ingredient of two types: R-lipoic acid (RLA) and S-lipoic acid (SLA). Natural ALA is RLA, while synthetic ALA is SLA, which is potentially inactive. Due to S’s low cost, a 50/50 mix of R and S forms is available and cheaper.
Most of the health benefits of ALA are attributed to R Lipoic Acid (RLA). As an antioxidant, RLA neutralizes harmful free radicals in the body and boosts cell energy. It has been proven that RLA has anti-inflammatory properties and is more effective than the combined R and S forms of ALA.
Importance of Antioxidants in the Body
Free radicals can damage your cells if antioxidants do not protect them. Free radicals can cause chronic diseases, oxidative stress, and inflammation. Free radicals are molecules generated by metabolic processes or external factors, like reactive oxygen species (ROS).
Achieving a balance between free radicals and antioxidants is crucial for a healthy body. Antioxidants like vitamins C and E play a key role in maintaining this balance. Vitamin C protects the aqueous part of cells, while vitamin E targets the cell membrane.
The body’s master antioxidant is glutathione. In cells, it neutralizes ROS and regenerates other antioxidants to reduce oxidative stress. In addition to detoxification, glutathione supports immunity.
As both water- and fat-soluble compounds, ALA and RLA provide specific benefits. Due to their dual properties, they exert powerful antioxidant effects throughout your body. It is important to know the differences between ALA and RLA in the context of antioxidants and cellular health.
Chemical Structure and Bioavailability
R-lipoic acid (R-LA) and S-lipoic acid (S-LA) are enantiomers. Enantiomers are mirror images of each other, and in the case of lipoic acid, the R-form is synthesized by the body and found in food sources. At the same time, the S-form is not biologically active.
In supplements, ALA is often a 50/50 mixture of both R-lipoic acid and S-lipoic acid, whereas R-lipoic acid (R-LA) is the pure, single-isomer form of the compound. Due to their distinct chemical structures, R-LA and S-LA exhibit differences in their bioavailability and efficacy.
Regarding bioavailability, R-lipoic acid is superior to the 50/50 R-LA and S-LA (ALA) mixture. Here’s a brief comparison of ALA and R-LA:
- ALA:
- 50% R-lipoic acid and 50% S-lipoic acid
- Lower bioavailability than R-LA
- R-LA:
- Pure, single-isomer form of lipoic acid
- Greater bioavailability than ALA
Research has shown that the R-form of lipoic acid is more bioavailable, up to twice as much as the S-form. This higher bioavailability makes R-LA more effective in exerting its antioxidant and anti-inflammatory properties.
Natural Occurrence and Supplement Form
RLA is the Natural, Biologically Active Form of Lipoic Acid Found in the Body and Some Foods
You can find R-lipoic acid in certain foods, and your body synthesizes it naturally. Lipoic acid is biologically active and is crucial in many of your body’s functions. Compared to the synthetic form, RLA is more accessible to the body, making it a superior antioxidant choice. Some food sources containing RLA include organ meats, spinach, broccoli, and potatoes.
ALA is Often Seen in Supplement Form Combined with S-Lipoic Acid
Alpha-lipoic acid (ALA) is often used in supplement form, and it mostly contains a combination of R-lipoic acid and S-lipoic acid in a 50/50 ratio. The S-lipoic acid is a synthetic form created during the manufacturing process. Still, it should be noted that the R-form is the one that is biologically active in your body. However, some information suggests that S-lipoic acid may have an analgesic effect.
RLA Provides 100 mg of Pure R-Isomer Alpha-Lipoic Acid per Vegan-Friendly Capsule
Regarding supplements, paying attention to their specific form of lipoic acid is essential. R-Lipoic Acid supplements provide 100 mg of the pure R-isomer per vegan-friendly capsule, ensuring you receive the full benefits without synthetic components. Vegans who consume fewer natural food sources of RLA may benefit particularly from these supplements. By choosing R-lipoic acid supplements, you can be confident that you’re using a natural and biologically active product that benefits your body and overall health.
Health Benefits
RLA is More Effective in Destroying Peroxynitrite Free Radicals
Despite the antioxidant properties provided by both ALA and RLA, studies have shown that R-lipoic acid is superior when breaking down peroxynitrite free radicals, which are harmful to your body. Since RLA can effectively neutralize these free radicals and promote overall vitality, it may offer enhanced protection against oxidative stress and aging than ALA.
Conclusion
R-Lipoic Acid (RLA) is more active than Alpha-Lipoic Acid (ALA) due to its higher bioavailability. RLA is the natural form of lipoic acid found in your body and some food sources, making it more easily recognized and utilized. Both ALA and RLA have antioxidant properties that can reduce oxidative stress, protect cells, and improve bodily functions. Supplementing with either form can contribute to a healthier lifestyle, but RLA is generally considered superior. It’s important to understand the differences between ALA and RLA when supplementing and making an informed decision.